Forschung
Lehrstühle und Arbeitskreise des Instituts
Pharmazeutische Bioinformatik:Klinische Pharmazie:
|
Pharmazeutische Biologie und Biotechnologie: |
|
Pharmazeutische und Medizinische Chemie: |
Pharmazeutische Technologie: |
Weitere Forschungsgruppen / Honorarprofessuren
|
Forschungsprojekte
Die Forschung ist eine der wichtigen Säulen der Pharmazeutischen Wissenschaften in Freiburg. Neben zahlreichen geförderten Projekten der DFG gibt es verschiedene laufende Forschungsverbundprojekte an denen die Arbeitskreise des Instituts beteiligt sind:
Unfolding the potential of SAM-dependent enzyme chemistry (Forschungsgruppe FOR 5596)
FOR 5596 aims to gain a comprehensive understanding of the fundamental reactivity of the cofactor SAM and fully exploit its synthetic potential. The versatile reactivity of the cofactor SAM enables various transformations that are controlled by the protein scaffold. Our goal is to understand the control and regulation of these reactivities and the underlying mechanisms using a comprehensive set of methods and approaches. The knowledge gained will be translated into efficient and flexible in vitro applications.
Medical Epigenetics (DFG Collaborative Research Centre 992)
Collaborative Research Centre 992 - Medical Epigenetics - from basic mechanisms to clinical applications Modern bioscience has entered a post-genomic era that is highlighted by seminal discoveries in the area of epigenetics. Normal development, cell type identities and disease require a better understanding of chromatin and of epigenetic control. The DNA sequence alone does not explain all aspects of heritable physiology and pathology. The CRC 992 »Medical Epigenetics«, MEDEP, provides a translational program for epigenetic research. Scientists from the University Freiburg Medical Centre, the University of Freiburg and the Max Planck Institute of Immunobiology and Epigenetics team up in a consortium that explores basic epigenetic mechanisms in cellular assays and explorative mouse models, validation of epigenetic control in animal models of disease, and translation of epigenetic principles to clinical applications.
Transport across and into membranes (DFG Research Training Group 2202)
The RTG focuses on the characterization of transport processes at a molecular level and the interaction of transport proteins with membranes. This highly challenging research field has a strong medical impact and the perspective of future growth. The aim of the RTG is to excellently qualify doctoral researchers by providing cutting-edge education and by strengthening interdisciplinary research in the field of ‘Transport across and into membranes’. The availability of manifold techniques within the RTG creates an excellent platform that enables doctoral researchers to acquire a broad spectrum of unique skills, providing them a wide selective advantage within the competitive job-market for scientists.
Technische Ausstattung
Neben der modernen Laborausstattung der verschiedenen Pharmazeutischen Disziplinen, die den Studierenden zur Verfügung steht, setzen die einzelnen Arbeitsgruppen zahlreiche Messapparaturen für laufende Forschungsprojekte ein. Dazu gehören z.B. NMR, LC-MS/MS, GC-MS, FTIR und VCD für analytische Messungen, High-Throughput Assays für zelluläre Tests oder Fermenter für biotechnologische Anwendungen. Mit dem BinAC steht ein großer Computercluster für das virtuelle Screening zur Verfügung. Neue kalorimetrische Messverfahren (z.B. ITC) und Asymmetrische Fluss-Feldflussfraktionierung (AF4) werden in der Pharmazeutischen Technologie eingesetzt.